| 000 | 02337nam a22003137a 4500 | ||
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| 003 | ZW-GwMSU | ||
| 005 | 20250321104435.0 | ||
| 008 | 250321b |||||||| |||| 00| 0 eng d | ||
| 022 | _a09743626 | ||
| 040 |
_aMSU _bEnglish _cMSU _erda |
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| 050 | 0 | 0 | _aQD31 JOU |
| 100 | 1 |
_aZhang, Hui Zhen _eauthor |
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| 245 | 1 | 0 |
_aSynthesis and bioactive evaluations of novel benzotriazole compounds as potential antimicrobial agents and the interaction with calf thymus DNA _ccreated by Yu Ren, Hui Zhen Zhang, Shao Lin Zhang, Yun Lei Luo, Ling Zhang, Cheng He Zhou and Rong Xia Geng |
| 264 | 1 |
_aBangalore : _bSpringer, _c2015. |
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| 336 |
_2rdacontent _atext _btxt |
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| 337 |
_2rdamedia _aunmediated _bn |
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| 338 |
_2rdacarrier _avolume _bnc |
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| 440 |
_aJournal of chemical sciences _vVolume 127, number 12, |
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| 520 | 3 | _aA novel series of benzotriazole derivatives were synthesized and characterized by NMR, IR and MS spectra. The bioactive assay manifested that most of the new compounds exhibited moderate to good antibacterial and antifungal activities against the tested strains in comparison to reference drugs chloromycin, norfloxacin and fluconazole. Especially, 2,4-dichlorophenyl substituted benzotriazole derivative 6f displayed good antibacterial activity against MRSA with MIC value of 4 μg/mL, which was 2-fold more potent than Chloromycin, and it also displayed 3-fold stronger antifungal activity (MIC = 4 μg/mL) than fluconazole (MIC = 16 μg/mL) against Beer yeast. The preliminary interactive investigations of compound 6f with calf thymus DNA revealed that compound 6f could effectively intercalate into DNA to form compound 6f–DNA complex which might block DNA replication to exert antimicrobial activities. Molecular docking experiments suggested that compound 6f projected into base-pairs of DNA hexamer duplex forming two hydrogen bonds with guanine of DNA. The theoretical calculations were in accordance with the experimental results. | |
| 650 |
_aBenzotriazole _vAntibacterial _xAntifungal |
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| 700 | 1 |
_aZhang, Hui Zhen _eco author |
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| 700 | 1 |
_aZhang, Shao Lin _eco author |
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| 700 | 1 |
_aLuo, Yun Lei _eco author |
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| 700 | 1 |
_aZhang, Ling _eco author |
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| 700 | 1 |
_aZhou,Cheng He _eco author |
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| 700 | 1 |
_aGeng, Rong Xia _eco author |
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| 856 | _uhttps://doi.org/10.1007/s12039-015-0991-y | ||
| 942 |
_2lcc _cJA |
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| 999 |
_c169436 _d169436 |
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