| 000 | 02236nam a22002657a 4500 | ||
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| 003 | ZW-GwMSU | ||
| 005 | 20250319072102.0 | ||
| 008 | 250319b |||||||| |||| 00| 0 eng d | ||
| 022 | _a09743626 | ||
| 040 |
_aMSU _bEnglish _cMSU _erda |
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| 050 | 0 | 0 | _aQD31 JOU |
| 100 | 1 |
_aRehana, Dilaveez _eauthor |
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| 245 | 1 | 0 |
_aHydroxy, carboxylic and amino acid functionalized superparamagnetic iron oxide nanoparticles : _bsynthesis, characterization and in vitro anti-cancer studies / _ccreated by Dilaveez Rehana, Azees Khan Haleel and Aziz Kalilur Rahiman |
| 264 | 1 |
_aBangalore : _bSpringer, _c2015. |
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| 336 |
_2rdacontent _atext _btxt |
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| 337 |
_2rdamedia _aunmediated _bn |
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| 338 |
_2rdacarrier _avolume _bnc |
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| 440 |
_aJournal of chemical sciences _vVolume 127, number 7, |
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| 520 | 3 | _aSuperparamagnetic iron oxide nanoparticles were synthesized by simple co-precipitation method and modified with different coating agents such as ascorbic acid, hexanoic acid, salicylic acid, L-arginine and L-cysteine. The synthesized nanoparticles were characterized by various techniques such as FT IR, XRD, VSM, SEM, TEM and thermal analysis. Both bare and coated magnetites were of cubic spinel structure and spherical in shape. All the magnetite nanoparticles showed superparamagnetic behaviour with high saturated magnetization. In vitro cytotoxicity test of bare and coated nanoparticles was performed using adenocarcinoma cells, A549. Cell viability of bare and L-arginine coated magnetite nanoparticles showed IC50 value of 31.2 μg/mL proving the compatibility of nanocarriers when compared to others. Hence, L-arginine coated nanoparticles were used for loading the drug paclitaxel and the observed IC50 value (7.8 μg/mL) shows its potent anti-proliferative effect against A549 lung cancer cell lines. Thus, it can be speculated that the drug paclitaxel loaded L-arginine coated nanoparticles could be used as an effective drug carrier for the destruction of cancer cells. | |
| 650 |
_aMagnetite nanoparticles _vAcid-coated magnetite nanoparticles _xCytotoxicity |
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| 700 | 1 |
_aHaleel, Azees Khan _eco author |
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| 700 | 1 |
_aRahiman, Aziz Kalilur _eco author |
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| 856 | _uhttps://doi.org/10.1007/s12039-015-0876-0 | ||
| 942 |
_2lcc _cJA |
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| 999 |
_c169354 _d169354 |
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