000			02079nam a22002897a 4500
003			ZW-GwMSU
005			20250306074042.0
008			250306b |||||||| |||| 00| 0 eng d
022			_a09743626
040			_aMSU _bEnglish _cMSU _erda
050			_aQD31 JOU
100	1		_aGarai, A. _eauthor
245	1	0	_aPolypyridyl iron(II) complexes showing remarkable photocytotoxicity in visible light / _ccreated by Aditya Garai, Uttara Basu, Ila Pant, Paturu Kondaiah and Akhil R Chakravarty
264	1		_aBangalore : _bSpringer, _c2015.
336			_2rdacontent _atext _btxt
337			_2rdamedia _aunmediated _bn
338			_2rdacarrier _avolume _bnc
440			_aJournal of chemical sciences _vVolume 127, number 4,
520	3		_aIron(II) complexes of polypyridyl ligands (B), viz. [Fe(B)2]Cl2 (1 and 2) of N, N, N-donor 2-(2-pyridyl)-1,10-phenanthroline (pyphen in 1) and 3-(pyridin-2-yl)dipyrido[3,2-a:2’,3’-c]phenazine (pydppz in 2), are prepared and characterized. They are 1:2 electrolytes in aqueous DMF. The diamagnetic complexes exhibit metal to ligand charge transfer band near 570 nm in DMF. The complexes are avid binders to calf thymus DNA giving binding constant (K b) values of ∼106 M−1 suggesting significant intercalative DNA binding of the complexes due to presence of planar phenanthroline bases. Complex 2 exhibits significant photocytotoxicity in immortalized human keratinocyte cells HaCaT and breast cancer cell line MCF-7 giving IC50 values of 0.08 and 13 μM in visible light (400–700 nm). Complex 2 shows only minor dark toxicity in HaCaT cells but is non-toxic in dark in MCF-7 cancer cells. The light-induced cellular damage follows apoptotic pathway on generation of reactive oxygen species as evidenced from the dichlorofluorescein diacetate (DCFDA) assay.
650			_aIron _vPolypyridyl bases _xDNA binding
700	1		_aBasu, U. _eco author
700	1		_aPant, I _eco author
700	1		_aKondaiah, P. _eco author
700	1		_aChakravarty, A. R. _eco author
856			_uhttp://doi.org/10.1007/s12039-015-0815-0
942			_2lcc _cJA
999			_c169154 _d169154