000			02155nam a22002777a 4500
003			ZW-GwMSU
005			20250219111341.0
008			250219b |||||||| |||| 00| 0 eng d
022			_a0176-1617
040			_aMSU _bEnglish _cMSU _erda
050	0	0	_aQK711.2 JOU
100	1		_aLee, Kyounghee _eauthor
245	1	0	_aHistone deacetylation-mediated cellular dedifferentiation in Arabidopsis _ccreated by Kyounghee Lee, Ok-Sun Park, Su-Jin Jung and Pil Joon Seo
264	1		_aAmsterdam: _bElsevier GmbH, _c2016.
336			_2rdacontent _atext _btxt
337			_2rdamedia _aunmediated _bn
338			_2rdacarrier _avolume _bnc
440			_aJournal of plant physiology _vVolume 191
520	3		_aChromatin structure determines the accessibility of transcriptional regulators to target DNA and contributes to regulation of gene expression. Posttranslational modifications of core histone proteins underlie the reversible changes in chromatin structure. Epigenetic regulation is closely associated with cellular differentiation. Consistently, we found that histone deacetylation is required for callus formation from leaf explants in Arabidopsis . Treatment with trichostatin A (TSA) led to defective callus formation on callus-inducing medium (CIM). Gene expression profiling revealed that a subset of HDAC genes, including HISTONE DEACETYLASE 9 (HDA9), HD-TUINS PROTEIN 1 (HDT1), HDT2, HDT4, and SIRTUIN 1 (SRT1), was significantly up-regulated in calli. In support of this, genetic mutations of HDA9 or HDT1 showed reduced capability of callus formation, probably owing to their roles in regulating auxin and embryonic and meristematic developmental signaling. Taken together, our findings suggest that histone deacetylation is intimately associated with the leaf-to-callus transition, and multiple signaling pathways are controlled by means of histone modification during cellular dedifferentiation.
650			_aArabidopsis _vCallus formation _xChromatin remodeling
700	1		_aPark, Ok-Sun _eco-author
700	1		_aJung, Su-Jin P _eco-author
700	1		_aSeo, Pil Joon _eco-author
856			_u10.1016/j.jplph.2015.12.006
942			_2lcc _cJA
999			_c169000 _d169000