000			03062nam a22002897a 4500
003			ZW-GwMSU
005			20241211072733.0
008			241211b |||||||| |||| 00| 0 eng d
020			_a9780128140796
040			_arda _bEnglish _cMSULIB _erda
050			_aQH438.5 MIL
100	1		_aMiller Gary W. _eauthor
245	1	4	_aThe exposome : _ba new paradigm for the environment and health / _ccreated by Gary W. Miller.
250			_aSecond edition
264			_bAcademic Press, an Imprint of Elsevier, _c2020.
300			_axxii, 275 pages : _c25 cm
336			_2rdacontent _atext
337			_2rdamedia _aunmediated _bn
338			_2rdacarrier _avolume _bnc
504			_aIncludes bibliography and index
505			_aFront Cover The Exposome Copyright Page Dedication Contents Biography Preface to the second edition Preface to the first edition 1. The exposome: purpose, definitions, and scope 1.1 Introduction 1.2 What is the exposome? 1.3 What is a paradigm? 1.4 What is the environment? 1.5 What is health? 1.6 Balkanization of the exposome 1.7 Darwin would be proud 1.8 If it is so obvious, why this book? 1.9 The exposome community 1.10 Tomayto, tomahto apoptosis, a-POP-tosis exposome, Xposome 1.11 Teaching/learning the exposome 1.12 Obstacles and opportunities 1.13 Discussion questions References Further reading 2. Genes, genomes, and genomics: advances and limitations 2.1 DNA, no longer a secret 2.2 The Human Genome Project: DNA at scale 2.3 Heritability 2.4 The gene versus environment continuum 2.4.1 A dangerous metaphor? 2.5 Large-scale genetics 2.6 Epigenetics: a clear gene-environment interface 2.7 Using genetic know-how to better understand environmental influences 2.8 Obstacles and opportunities 2.9 Discussion questions References Further reading 3. Nurturing science 3.1 Introducing nurture 3.2 Nutrition: feeding our exposome 3.3 Too much of a good thing 3.4 Dietary insight from the laboratory 3.5 Physical activity-exercising your exposome 3.6 Psychosocial interactions and cognitive development: your humanity and the exposome 3.7 What actions can the Example family take to improve their exposome? 3.8 Immunity and the exposome 3.9 Nurture and evolution 3.10 Evaluating nurture 3.11 Tick-tock, tick-tock. Is that my epigenetic clock? 3.12 Obstacles and opportunities 3.13 Discussion questions 5.5 Proteome 5.6 Pharmacogenomics/toxicogenomics 5.7 Epigenomics 5.8 Metabolome 5.9 What to do with all of these -omes 5.10 The exposome and exposomics 5.11 Obstacles and opportunities 5.12 Discussion questions References Further reading 6. Innovation and the exposome 6.1 Introduction 6.2 A pile of something 6.3 Moonshots and missed shots 6.4 Great by association 6.5 Acceptable failure, intolerable incompetence 6.6 A brief history of time (of flight) and other technologies 6.7 Measuring the previously unmeasurable 6.8 The science of innovation
650		2	_aEnvironmental exposure _xAdverse effects
650		2	_aEnvironmentally induced diseases
650		2	_aExposome
650		2	_aGenome
942			_2lcc _cB
999			_c168758 _d168758