000 02346nam a22003377a 4500
999 _c152118
_d152118
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005 20200619104325.0
008 200310b ||||| |||| 00| 0 eng d
020 _a9780128022573
040 _bEnglish
_cMSU
_erda
041 _aeng
050 _aRC349.8 MOL
245 0 0 _aMolecular and cellular therapies for motor neuron diseases
_cNicholas Boulis, Deirdre O'Connor and Anthony Donsante
264 1 _aLondon :
_bElsevier, Academic Press,
_c2017.
264 4 _c©2017.
300 _a321 pages :
_billustrations ;
_c24 cm
336 _atext
_btxt
_2rdacontent
337 _aunmediated
_bn
_2rdamedia
338 _avolume
_bnc
_2rdacarrier
504 _aIncludes bibliographical references and index.
505 0 _a1. Molecular and extracellular cues in motor neuron specification and differentiation / R.L. Swetenburg, S.L. Stice and L. Karumbaiah -- 2. Natural history of amyotrophic lateral sclerosis / M.J. Magnussen and J.D. Glass -- 3. Genetics of amyotrophic lateral sclerosis / K.P. Kenna, J.E. Landers and N. Ticozzi -- 4. Molecular mechanisms of amytrophic lateral sclerosis / M. Collins and R. Bowser -- 5. An introduction to natural history, genetic mapping, and clinical spectrum of spinal muscular atrophy / A. McDonough, L. Urquia and N. Boulis -- 6. Genetics of spinal muscular atrophy / A.H.M. Burghes and V.L. McGovern -- 7. Introduction to gene and stem-cell therapy / D.M. O'Connor -- 8. Gene therapy for amytrophic lateral sclerosis / A. Dosante -- 9. Stem cell therapy for amytrophic lateral sclerosis / K.S. Chen and E.L. Feldman -- 10. Gene therapy for spinal muscular atrophy / M.R. Miller, E.Y. Osman and C.L. Lorson -- 11. Cellular therapy for spinal muscular atrophy / I. Faravelli and S. Corti -- 12. Clinical trials to date / B.J. Mader and N. Boulis.
650 0 _aMotor neurons
_xDiseases
_xTreatment
650 0 _aNeuromuscular diseases
_xTreatment
650 1 2 _aMotor Neuron Disease
_xTherapy
650 2 2 _aMolecular Targeted Therapy
_xMethods
650 2 2 _aCell- and Tissue-Based Therapy
_xMethods
700 1 _aBoulis, Nicholas
_eEditor
_eEmory University, Atlanta, GA, United States
700 1 _aO'Connor, Deirdre M.
_eEditor
_eEmory University, Atlanta, GA, United States
700 1 _aDonsante, Anthony
_eEditor
_eEmory University, Atlanta, GA, United States
942 _2lcc
_cB