The exposome : a new paradigm for the environment and health / created by Gary W. Miller.

Includes bibliography and index

Front Cover The Exposome Copyright Page Dedication Contents Biography Preface to the second edition Preface to the first edition 1. The exposome: purpose, definitions, and scope 1.1 Introduction 1.2 What is the exposome? 1.3 What is a paradigm? 1.4 What is the environment? 1.5 What is health? 1.6 Balkanization of the exposome 1.7 Darwin would be proud 1.8 If it is so obvious, why this book? 1.9 The exposome community 1.10 Tomayto, tomahto apoptosis, a-POP-tosis exposome, Xposome 1.11 Teaching/learning the exposome 1.12 Obstacles and opportunities 1.13 Discussion questions References Further reading 2. Genes, genomes, and genomics: advances and limitations 2.1 DNA, no longer a secret 2.2 The Human Genome Project: DNA at scale 2.3 Heritability 2.4 The gene versus environment continuum 2.4.1 A dangerous metaphor? 2.5 Large-scale genetics 2.6 Epigenetics: a clear gene-environment interface 2.7 Using genetic know-how to better understand environmental influences 2.8 Obstacles and opportunities 2.9 Discussion questions References Further reading 3. Nurturing science 3.1 Introducing nurture 3.2 Nutrition: feeding our exposome 3.3 Too much of a good thing 3.4 Dietary insight from the laboratory 3.5 Physical activity-exercising your exposome 3.6 Psychosocial interactions and cognitive development: your humanity and the exposome 3.7 What actions can the Example family take to improve their exposome? 3.8 Immunity and the exposome 3.9 Nurture and evolution 3.10 Evaluating nurture 3.11 Tick-tock, tick-tock. Is that my epigenetic clock? 3.12 Obstacles and opportunities 3.13 Discussion questions 5.5 Proteome 5.6 Pharmacogenomics/toxicogenomics 5.7 Epigenomics 5.8 Metabolome 5.9 What to do with all of these -omes 5.10 The exposome and exposomics 5.11 Obstacles and opportunities 5.12 Discussion questions References Further reading 6. Innovation and the exposome 6.1 Introduction 6.2 A pile of something 6.3 Moonshots and missed shots 6.4 Great by association 6.5 Acceptable failure, intolerable incompetence 6.6 A brief history of time (of flight) and other technologies 6.7 Measuring the previously unmeasurable 6.8 The science of innovation