Lanzkowsky's manual of pediatric hematology and oncology / edited by Philip Lanzkowsky, MD Jeffrey M. Lipton, MD, PhD Jonathan D. Fish.

Includes index

Front Cover Lanzkowsky's Manual of Pediatric Hematology and Oncology Copyright Page Dedication Contents List of contributors About the Editors Philip LanzkowskyFounding Author and Editor Jonathan D. Fish Managing Editor Jeffrey M. Lipton Preface to the seventh edition Preface to the sixth edition Preface to the fifth edition Preface to the fourth edition Preface to the third edition Preface to the second edition Preface to the first edition Introduction: Historic perspective (1955-2015) Reflection on 60 years of progress in pediatric hematology/oncology 1 Molecular and genomic methodologies for clinicians Clinical molecular and genomic methodologies: goals Methods of genetic analysis Markers of genetic defects Sequencing approaches Sanger sequencing Next-generation sequencing technologies and applications Interpretation of genetic variants obtained from next-generation sequencing Applications of next-generation sequencing to oncology Clinical interpretation of sequence variants in cancer Liquid tumor biopsies Epigenetic sequencing Single-cell sequencing Interpreting and evaluating the results from clinical genetic testing Further reading and references 2 Hematologic manifestations of systemic illness Alterations to red blood cells related to organ-specific pathologies Cardiovascular system Anemia Erythrocytosis Qualitative changes to RBC morphology Lungs Anemia Erythrocytosis Gastrointestinal tract Anemia Pancreas Anemia Liver Anemia Kidneys Anemia Endocrine system Anemia Erythrocytosis Skin Eczema and psoriasis Dermatitis herpetiformis Dyskeratosis congenita Alterations to white blood cells related to organ-specific pathologies Cardiovascular system Gastrointestinal tract Spleen Endocrine system Skin Mast cell disease Alterations to platelets and coagulation related to organ-specific pathologies Cardiovascular system Gastrointestinal tract Liver Thrombocytopenia Coagulation abnormalities Skin Ehlers-Danlos syndrome General considerations for the hematologic sequelae of infection Anemia White cell alterations Clotting abnormalities Thrombocytopenia Viral and bacterial illnesses associated with marked hematologic sequelae Parvovirus Epstein-Barr virus TORCHES infections Salmonella typhi Acute infectious lymphocytosis Bartonellosis Tuberculosis Leptospirosis (Weil disease) Severe acute respiratory syndrome coronavirus 2 Human immunodeficiency virus Thrombocytopenia Anemia and neutropenia Coagulation abnormalities Role of hematopoietic growth factors in treatment of AIDS-associated cytopenia Cancers in children with human immunodeficiency virus infection HIV-associated lymphoma Proliferative lesions of mucosa-associated lymphoid tissue

"Designed to be easily readable and highly practical with over 400 illustrative tables, along with color diagrams and figures New chapter on Pediatric Vascular Anomalies New content on 'blood avoidance' programs to honor religious preferences Discussions of new drugs and immunological therapies for cancers, along with discussions of increasing use of cytokine stimulants for hematologic disorders Includes practical genetic evaluations providing a deeper understanding and advances in management of bone marrow failure diseases"--