Drug discovery in cancer epigenetics edited by Gerda Egger and Paola Arimondo

Includes bibliographical references and index

I. Introduction. Basic epigenetic mechanisms and phenomena -- Cancer epigenetics -- II. Methods and tools for epigenetic drug development -- Drug discovery methods -- Preclinical cancer models with the potential to predict clinical response -- Discovery of biomarkers for drug development -- Networks and consortia for epigenetic drug discovery -- III. Classes of epigenetic drugs -- DNA methyltransferase inhibitors -- Small molecule inhibitors of histone deacetylases and acetyltransferases as potential therapeutics in oncology -- Targeting histone methylation. The development of selective methyltransferase and demethylase inhibitors -- Bromodomains as anti-cancer targets -- Epigenetic readers interpreting the lysine methylome: biological roles and drug discovery -- Non coding RNAs: clinical and therapeutic applications -- IV. Clinical implications of epigenetic therapy. Clinical applications of epigenetic drugs -- Efficacy of combined epigenetic therapies -- Predicting and monitoring responses to epigenetic drugs -- Episensitization: a new word for a new concept -- The emerging potential for epigenetic therapeutics in non-cancer disorders