TY  - BOOK
AU  - Egger, Gerda 
AU  -  Arimondo,  Paola
TI  - Drug discovery in cancer epigenetics
T2  - Translational epigenetics series
SN  - 9780128022085
PY  - 2016///
CY  - Oxford : 
PB  -  Elsevier, 
KW  - Cancer
KW  - Genetic aspects 	
KW  - Epigenetics 	
KW  - Neoplasms
KW  - drug therapy 	
KW  - Gene expression 	
KW  - Drug development 	
KW  - genetics 	
N1  - Includes bibliographical references and index; I. Introduction. Basic epigenetic mechanisms and phenomena -- Cancer epigenetics -- II. Methods and tools for epigenetic drug development -- Drug discovery methods -- Preclinical cancer models with the potential to predict clinical response -- Discovery of biomarkers for drug development -- Networks and consortia for epigenetic drug discovery -- III. Classes of epigenetic drugs -- DNA methyltransferase inhibitors -- Small molecule inhibitors of histone deacetylases and acetyltransferases as potential therapeutics in oncology -- Targeting histone methylation. The development of selective methyltransferase and demethylase inhibitors -- Bromodomains as anti-cancer targets -- Epigenetic readers interpreting the lysine methylome: biological roles and drug discovery -- Non coding RNAs: clinical and therapeutic applications -- IV. Clinical implications of epigenetic therapy. Clinical applications of epigenetic drugs -- Efficacy of combined epigenetic therapies -- Predicting and monitoring responses to epigenetic drugs -- Episensitization: a new word for a new concept -- The emerging potential for epigenetic therapeutics in non-cancer disorders
ER  -