TY - BOOK AU - OHLS Robin K. AU - Maheshwari,Akhil AU - Polin Richard A. TI - Hematology, immunology, and infectious disease: neonatology questions and controversies T2 - Neonatology questions and controversies series SN - 9781437726626 (hbk) AV - RJ269.5 OHL PY - 2012/// CY - Philadelphia PB - Elsevier Saunders KW - Neonatal hematology KW - Newborn infants KW - Immunology KW - Communicable diseases in newborn infants N1 - Includes bibliographical references and index; Front Cover; IFC; Neonatology Questions and Controversies; Neonatology Questions and Controversies; Neonatology Questions and Controversies; Copyright; Contributors; Series Foreword; Preface; Contents; 1 -- Stem Cell Therapy in Neonates-the Time Has (Almost) Come; Stem cells: important in development and disease; Mesenchymal stromal cells: orchestrator of immune response and healing processes; Endothelial colony-forming cells: when angiogenesis counts; Amnion epithelial cells-don't discount the placenta; Bronchopulmonary dysplasia and stem cell therapy Prophylactic mesenchymal stromal cell therapyRescue mesenchymal stromal cell therapy; It's in the juice-MSCs act via a paracrine effect; Other stem cells for bronchopulmonary dysplasia; Endothelial progenitor cells and endothelial colony-forming cells; Human amnion epithelial cells; Summary; Mesenchymal stromal cell therapy for neurologic diseases of newborn; Intraventricular hemorrhage; Hypoxic-ischemic encephalopathy; Neonatal stroke; Mesenchymal stromal cells for congenital heart disease; Mechanisms of action of stem cells in neonatal diseases; Stem cells targeting the immune response Stem cells and growth factorsExtracellular vesicles: exosomes and microvesicles; Summary; Clinical stem cell trials; Completed stem cell trials for neonatal diseases; Lessons from nonneonatal stem cell trials; Going forward-has the time come?; Conclusion; REFERENCES; 2 -- Genome and Exome Sequencing: Can It Impact Clinical Care in the Neonatal Intensive Care Unit?; Next-generation sequencing; Genome vs. exome vs. targeted-panel sequencing; Clinical utility of next-generation sequencing in neonatal intensive care unit; Newborn screening; Future perspectives; REFERENCES 3 -- Transfusion Thresholds in the Neonatal Intensive Care Unit: What Have Recent Randomized Controlled Trials Taught Us?Transfusion risks; When to transfuse; Acute anemia; Chronic anemia; Preoperative target for infants undergoing surgery; Studies evaluating target hemoglobin or hematocrit; Erythropoiesis-stimulating agents and transfusions; Search for other transfusion markers; Selection of red cell products; Red cell transfusion volumes; When families oppose transfusions; Summary and recommendations; REFERENCES; 4 -- Donor Milk Compared with Mother's Own Milk; Secretory immunoglobulin A LactoferrinLysozyme; Epidermal growth factor; Lipase; Oligosaccharides; Transforming growth factor; Cytokines and chemokines; Cells; Erythropoietin; Summary; REFERENCES; 5 -- Will Standardized Approaches to Nutrition Decrease Necrotizing Enterocolitis?; General approach to enteral feeding to prevent necrotizing enterocolitis in preterm infants; Enteral feeding during treatment for patent ductus arteriosus; Enteral feedings and red blood cell transfusions; Quality improvement framework; Conclusion; REFERENCES; 6 -- Nonimmune Neonatal Hemolytic Anemia: Recent Advances in Diagnosis and Treatment ER -