Middleton's allergy : principles and practice / edited by A. Wesley Burks, MD, Stuart Bondurant Distinguished Professor, Dean and CEO, UNC School of Medicine and UNC Health Care, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, Stephen T. Holgate, Robyn E. O'Hehir, David H. Broide, Leonard B. Bacharier, Gurjit K. Khurana and R. Stokes Peebles..

Includes bibliographical references and index.

Volume 1. Section A. Basic Sciences Underlying Allergy and Immunology Innate immunity Adaptive immunity Immunoglobulin structure and function Immune tolerance Cytokines in allergic inflammation Cellular adhesion in inflammation Chemokines The complement system Lipid mediators of hypersensitivity and inflammation Molecular biology and genetic engineering Biology of lymphocytes Innate lymphoid cells Antigen-presenting dendritic cells Biology of mast cells and their mediators Biology of basophils Biology of eosinophils Biology of neutrophils Biology of monocytes and macrophages Airway epithelial cells Airway smooth muscle in asthma Pathophysiology of allergic inflammation Genetics and epigenetics in allergic diseases and asthma Systems biology Immunobiology of IgE and IgE receptors Neuronal control of airway function in allergy Section B. Aerobiology and Allergens The structure and function of allergens Aerobiology of outdoor allergens Indoor allergens Preparation and standardization of allergen extracts Air pollution : Indoor and outdoor Effect of the food matrix and processing on the allergenic activity of foods Section C. The Skin Structure of the skin and cutaneous immunology Atopic dermatitis Contact dermatitis Urticaria and angioedema Hereditary angioedema and Bradykinin-mediated angioedema Immune complexes and allergic disease Section D. The Eye Allergic and immunologic diseases of the eye Section E. Respiratory Tract The nose and control of nasal airflow Allergic and nonallergic rhinitis Rhinosinusitis and nasal polyps Development, structure and physiology in normal lung and in asthma Respiratory tract mucosal immunology Airway mucus and mucociliary system Epidemiology of asthma and allergic diseases Ontogeny of immune development and its relationship to allergic diseases and asthma Asthma pathogenesis Mouse models of allergic airways disease Diagnosis of asthma in infants and children Management of asthma in infants and children Diagnosis of asthma in adults Management of asthma in adolescents and adults Emergency treatment and approach to the patient with acute asthma Approach to the patient with exercise-induced bronchoconstriction Asthma and allergic diseases during pregnancy Occupational allergy and asthma Pathology of asthma Allergic bronchopulmonary aspergillosis, hypersensitivity pneumonitis, and epidemic thunderstorm asthma Immunologic nonasthmatic diseases of the lung Approach to the patient with chronic cough Bronchial and nasal challenge testing Lung imaging Aerosols and aerosol drug delivery systems Volume 2. Section F. Gastrointestinal Tract Gastrointestinal mucosal immunology Eosinophilic gastrointestinal disorders Section G. Systemic Disease Clinical significance of immunoglobulin E In vivo methods for the study and diagnosis of allergy Approach to the patient with recurrent infections Primary immunodeficiency diseases Treatment of primary immunodeficiency diseases HIV infection and allergic disease Laboratory tests for allergic and immunodeficiency diseases Eosinophilia and eosinophil-related disorders Mastocytosis Anaphylaxis Insect allergy Drug allergy Hypersensitivity to aspirin and other nonsteroidal antiinflammatory drugs Reactions to foods Reactions to food and drug additives Oral food challenge testing Food allergy management Adverse reactions to vaccines Section H. Therapeutics Allergen control for prevention and management of allergic diseases Injection immunotherapy for inhalant allergens Sublingual immunotherapy for inhalant allergens Principles of pharmacotherapeutics Precision medicine in allergic disorders Adherence Anti-immunoglobulin E therapy Cytokine-specific therapy in asthma Histamine and antihistamines Inhaled [beta] 2-agonists Xanthines, phosphodiesterase inhibitors, and chromones Anticholinergic therapies Glucocorticoids Antileukotriene therapy in asthma Unconventional theories and unproven methods in allergy Complementary and alternative medicine Appendix A. CD molecules Index

"The worldwide leading text on allergy and immunology. Through eight outstanding editions, Middleton's Allergy : Principles and Practice has been the reference of choice for both clinicians and researchers as both a practical reference and an effective self-assessment tool for board preparation. The Ninth Edition continues the tradition of excellence with comprehensive coverage of all basic science and clinical applications regarding allergy practice and disease mechanisms. It brings you fully up to date with recent innovations in the diagnosis, prevention, and management of allergic disorders, including emerging global issues, the advent of precision medicine, and new immunologic therapies. Offers unparalleled depth and up-to-date guidance on the full spectrum of allergy across the lifespan, with significant updates throughout. Contains new chapters on Innate Lymphoid Cells, Systems Biology, and Treatment of Primary Immunodeficiency Diseases. Discusses emerging topics such as epidemic thunderstorm asthma and precision medicine in allergic disorders. Features more than 730 illustrations, including many new cellular and molecular drawings of disease mechanisms. Includes new Summary of Important Concepts boxes, plus new multiple-choice questions online with explanations and answers. Features a new team of expert editors and more international contributors for a global perspective of this complex field."--taken from back cover