Williams hematology / edited by Kenneth Kaushansky; MD, MACP; Senior Vice President, Health Sciences, Dean, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, Josef T. Prchal; MD; Professor of hematology and malignant hematology, Adjunct in genetics and pathology, University of Utah & Huntsman Cancer Institute, Salt Lake City, Utah, Linda J. Burns; MD; Consultant and senior scientific director, Center for international blood and marrow transplant research, Milwaukee, Wisconsin, Marshall A. Litchman; MD, MACP; Professor Emeritus of medicine and biochemistry and biophysics, Dean Emeritus, School of Medicine and dentistry, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, Marcel Levi; MD, PhD, FRCP; Professor of Medicine, University College London Hospitals, London, United Kingdom, Professor of Medicine, University of Amsterdam, Amsterdam, The Netherlands, and David C. Linch; FRCP, FRCPPath, FMed Sci; Professor of Hematology, Cancer program director, UCL/UCLH Biomedical research Centre, University College London, London, United Kingdom....[et al.]

Includes bibliography and index.

Part I: Clinical Evaluation of the Patient Chapter 1: Initial Approach to the Patient: History and Physical Examination Chapter 2: Examination of Blood and Marrow Cells Chapter 3: Consultative Hematology Part II: The Organization of the Lymphohematopoietic Tissues Chapter 4: Structure of the Marrow and the Hematopoietic Microenvironment Chapter 5: The Organization and Structure of Lymphoid Tissues Part III: Epochal Hematology Chapter 6: Hematology of the Fetus and Newborn Chapter 7: Hematology During Pregnancy Chapter 8: Hematology in Older Persons Part IV: Molecular and Cellular Hematology Chapter 9: Genetic Principles and Molecular Biology Chapter 10: Genomics and Epigenomics Chapter 11: Cytogenetic and Genetic Abnormalities Chapter 12: Application of Big Data and Deep Learning in Hematology Chapter 13: Metabolism of Hematologic Neoplastic Cells Chapter 14: Cell Death Chapter 15: Cell-Cycle Regulation and Hematologic Disorders Chapter 16: Signal Transduction Pathways Chapter 17: Hematopoietic Stem Cells, Progenitors, and Cytokines Chapter 18: The Inflammatory Response Chapter 19: Innate Immunity Chapter 20: The Biology of Innate Lymphoid Cells and Natural Killer Cells Chapter 21: Dendritic Cells and Adaptive Immunity Part V: Therapeutic Principles Chapter 22: Immune Checkpoint Inhibitors Chapter 23: Immune Cell Therapy: Chimeric Antigen Receptor T-Cell Therapy Chapter 24: Immune Cell Therapy: Dendritic Cell and Natural Killer Cell Therapy Chapter 25: Vaccine Therapy Chapter 26: Gene Therapy for Hematologic Diseases Chapter 27: Regenerative Medicine: Induced Pluripotent Stem Cells And Blood Cell Engineering Chapter 28: Pharmacology and Toxicity of Antineoplastic Drugs Chapter 29: Hematopoietic Stem Cell Transplantation Chapter 30: Therapeutic Apheresis: Indications, Efficacy, and Complications Chapter 31: Treatment of Infections in the Immunocompromised Host Chapter 32: Antithrombotic Therapy Part VI: The Erythrocyte Chapter 33: Structure and Composition of the Erythrocyte Chapter 34: Erythropoiesis and Red Cell Turnover Chapter 35: Clinical Manifestations and Classification of Erythrocyte Disorders Chapter 36: Aplastic Anemia: Acquired and Inherited Chapter 37: Pure Red Cell Aplasia Chapter 38: Anemia of Chronic Disease Chapter 39: Erythropoietic Effects of Endocrine Disorders Chapter 40: The Hereditary Dyserythropoietic Anemias Chapter 41: Paroxysmal Nocturnal Hemoglobinuria Chapter 42: Folate, Cobalamin, and Megaloblastic Anemias Chapter 43: Iron Metabolism Chapter 44: Iron Deficiency and Overload Chapter 45: Anemia Resulting from Other Nutritional Deficiencies Chapter 46: Anemia Associated with Marrow Infiltration Chapter 47: Erythrocyte Membrane Disorders Chapter 48: Erythrocyte Enzyme Disorders Chapter 49: Thalassemia: A Disorder of Globin Synthesis Chapter 50: Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities Chapter 51: Methemoglobinemia and Other Dyshemoglobinemias Chapter 52: Fragmentation Hemolytic Anemia Chapter 53: Erythrocyte Disorders as a Result of Toxic Agents Chapter 54: Hemolytic Anemia Resulting from Infections with Microorganisms Chapter 55: Hemolytic Anemia Resulting from Immune Injury Chapter 56: Alloimmune Hemolytic Disease of the Fetus and Newborn Chapter 57: Hypersplenism and Hyposplenism Chapter 58: Primary and Secondary Erythrocytoses/Polycythemias Chapter 59: The Porphyrias Chapter 60: Polyclonal and Hereditary Sideroblastic Anemias Part VII: Neutrophils, Eosinophils, Basophils, and Mast Cells Chapter 61: Structure and Composition of Neutrophils, Eosinophils, and Basophils Chapter 62: Classification and Clinical Manifestations of Neutrophil Disorders Chapter 63: Neutropenia and Neutrophilia Chapter 64: Disorders of Neutrophil Function Chapter 65: Eosinophils and Their Disorders Chapter 66: Basophils and Mast Cells and Their Disorders Part VIII: Monocytes and Macrophages Chapter 67: Structure, Receptors, and Functions of Monocytes and Macrophages Chapter 68: Production, Distribution, and Activation of Monocytes and Macrophages Chapter 69: Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages Chapter 70: Monocytosis and Monocytopenia Chapter 71: Inflammatory and Malignant Histiocytosis Chapter 72: Gaucher Disease and Related Lysosomal Storage Diseases Part IX: Lymphocytes and Plasma Cells Chapter 73: The Structure of Lymphocytes and Plasma Cells Chapter 74: Lymphopoiesis Chapter 75: Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production Chapter 76: Functions of T Lymphocytes: T-Cell Receptors for Antigen Chapter 77: Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders Chapter 78: Lymphocytosis and Lymphocytopenia Chapter 79: Immunodeficiency Diseases Chapter 80: Hematologic Manifestations of Human Immunodeficiency Virus and the Acquired Immunodeficiency Syndrome Chapter 81: Mononucleosis Syndromes Part X: Malignant Myeloid Diseases Chapter 82: Classification and Clinical Manifestations of the Clonal Myeloid Disorders Chapter 83: Polycythemia Vera Chapter 84: Essential Thrombocythemia Chapter 85: Primary Myelofibrosis Chapter 86: Myelodysplastic Syndromes Chapter 87: Acute Myelogenous Leukemia Chapter 88: Chronic Myelogenous Leukemia and Related Disorders Part XI: Malignant Lymphoid Diseases Chapter 89: Classification of Malignant Lymphoid Disorders Chapter 90: Acute Lymphoblastic Leukemia Chapter 91: Chronic Lymphocytic Leukemia Chapter 92: Hairy Cell Leukemia Chapter 93: Large Granular Lymphocytic Leukemia Chapter 94: General Considerations of Lymphomas: Incidence Rates, Etiology, Diagnosis, Staging, and Primary Extranodal Disease Chapter 95: Pathology of Lymphomas Chapter 96: Hodgkin Lymphoma Chapter 97: Diffuse Large B-Cell Lymphoma and Related Diseases Chapter 98: Follicular Lymphoma Chapter 99: Mantle Cell Lymphoma Chapter 100: Marginal Zone B-Cell Lymphomas Chapter 101: Burkitt Lymphoma Chapter 102: Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sézary Syndrome) Chapter 103: Mature T-Cell and Natural Killer Cell Lymphomas Chapter 104: Plasma Cell Neoplasms: General Considerations Chapter 105: Essential Monoclonal Gammopathy Chapter 106: Myeloma Chapter 107: Immunoglobulin Light Chain Amyloidosis Chapter 108: Macroglobulinemia Chapter 109: Heavy-Chain Disease Part XII: Hemostasis and Thrombosis Chapter 110: Megakaryopoiesis and Thrombopoiesis Chapter 111: Platelet Morphology, Biochemistry, and Function Chapter 112: Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis Chapter 113: Control of Coagulation Reactions Chapter 114: Vascular Function in Hemostasis Chapter 115: Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis Chapter 116: Thrombocytopenia Chapter 117: Heparin-Induced Thrombocytopenia Chapter 118: Hereditary and Reactive Thrombocytosis Chapter 119: Inherited Platelet Disorders Chapter 120: Acquired Qualitative Platelet Disorders Chapter 121: The Vascular Purpuras Chapter 122: Hemophilia A and Hemophilia B Chapter 123: Inherited Deficiencies of Coagulation Factors II, V, V+VIII, VII, X, XI, and XIII Chapter 124: Hereditary Fibrinogen Abnormalities Chapter 125: VON Willebrand Disease Chapter 126: Antibody-Mediated Coagulation Factor Deficiencies Chapter 127: Disseminated Intravascular Coagulation Chapter 128: Thrombotic Microangiopathies Chapter 129: Hemolytic Uremic Syndrome Chapter 130: Hemostatic Alterations In Liver Diseases and Liver Transplantation Chapter 131: Hereditary Thrombophilia Chapter 132: The Antiphospholipid Syndrome Chapter 133: Venous Thrombosis Chapter 134: Atherothrombosis: Disease Initiation, Progression, and Treatment Chapter 135: Fibrinolysis and Thrombolysis Part XIII: Transfusion Medicine Chapter 136: Erythrocyte Antigens and Antibodies Chapter 137: Human Leukocyte and Platelet Antigens Chapter 138: Blood Procurement and Red Cell Transfusion Chapter 139: Preservation and Clinical use of Platelets Chapter 140: Using Plasma and Plasma Component Therapy

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