Introduction to cancer metastasis edited by Aamir Ahmad

Includes bibliographical references and index.

List of contributors -- Preface -- I CANCER METASTASIS FROM PRIMARY ORGANS -- 1 CANCER METASTASIS: AN INTRODUCTION -- 1. Introduction -- 2. Disruption of Cell Adhesion: Initiation of Metastasis -- 3. Matrix Metalloproteinases in Cancer Metastasis -- 4. EMT in Cancer Metastasis -- 5. Organ-Specific Metastasis -- 6. microRNAs and Cancer Stem Cells in Cancer Metastasis -- 7. Conclusions and Perspectives -- 2. BREAST CANCER METASTASIS -- 1. Introduction -- 2. Biology -- 3. Metastatic Dissemination -- 4. Prognostic Factors After Recurrence -- 5. Treatment for Metastatic Breast Cancer -- 6. Conclusions -- 3. PROSTATE CANCER METASTASIS -1. Epidemiology and Overview of Metastatic Prostate Cancer -- 2. Cellular Biology of Prostate Cancer Metastases -- 3. The Metastatic Cascade -- 4. Conclusions -- 4. LUNG CANCER METASTASIS -- 1. General Information -- 2. Mechanism of Metastasis -- 3. Molecular Mechanism in the Regulation of Lung Cancer Metastasis -- 4. Epithelial to Mesenchymal Transition in Lung Cancer -- 5. Cancer Stem Cells -- 6. Concluding Remarks -- 5. CERVICAL CANCER METASTASIS -- 1. Introduction -- 2. Risk Factors -- 3. Pathogenesis -- 4. Histopathology -- 5. Routes of Dissemination -- 6. Major Molecular Factors -- 7. Conclusion -- 6. COLORECTAL CANCER METASTASIS -- 1. Introduction -- 2. Molecular Aspects of Colorectal Cancer Metastasis -- 3. Main Sites of Colorectal Cancer Metastasis -- 4. Therapeutic Options for Metastatic Colorectal Cancer -- 5. Challenges and Probable Solutions -- 6. Conclusions -- 7. METASTATIC PANCREATIC CANCER: CURRENT STATE AND FUTURE DIRECTIONS -- 1 Introduction -- 2 Management of pancreatic ductal adenocarcinoma -- 3 Molecular mechanisms driving metastasis -- 4 In vivo experimental models -- 5 Open question: onset and dynamics of metastasis -- 6 Conclusions -- 8 GASTRIC CANCER METASTASIS -- 1 Epidemiology and screening programs -- 2 Metastatic GC -- clinical aspects -- 3 Diagnosis of metastatic GC with a particular focus on 18-F-FDG PET/CT -- 4 Prognostic and predictive factors -- 5 Biomarkers -- 6 Treatment methods of metastatic GC -- 7 Conclusion -- 9 HEPATOCELLULAR CARCINOMA: METASTATIC DISEASE -- 1 Introduction -- 2 Epidemiology -- 3 Diagnosis -- 4 Prognosis and staging -- 5 Treatment -- 6 Conclusions -- 10 METASTATIC BLADDER CANCER -- 1 Introduction -- 2 Epidemiology -- 3 Staging -- 4 Grading -- 5 Staging tools -- 6 Emerging biomarkers -- 7 Prognostic factors -- 8 Clinical presentation of metastatic bladder disease -- 9 Management of clinically localized bladder cancer, positive pelvic nodes and metastatic disease -- 10 Clinical prognosticators -- 11 Management of metastatic bladder cancer -- 12 New agents -- 13 Immunotherapy -- 14 Role of surgery in metastatic bladder cancer -- 15 Conclusions -- 11 METASTATIC CUTANEOUS SQUAMOUS CELL CARCINOMAS -- 1 Introduction -- 2 Defining the high-risk variant -- 3 Staging systems -- 4 Treating high-risk cutaneous squamous cell carcinoma -- 5 Sentinel node biopsy -- 6 Treatment of locally advanced or metastatic cutaneous squamous cell carcinoma -- 7 Concluding remarks -- 12 OSTEOSARCOMA METASTASIS-PROGNOSTIC FACTORS AND TREATMENT STRATEGIES -- 1 Introduction -- 2 Clinical features of metastasis from osteosarcoma -- 3 Treatment for metastasis from osteosarcoma -- 4 Conclusion -- II CANCER METASTASIS TO DISTANT ORGANS -- 13 LYMPH NODE METASTASIS -- 1 Introduction -- 2 History -- 3 Mechanisms-how tumors metastasize to lymph nodes -- 4 Clinical aspects of lymph node metastasis -- 5 Pathology -- 6 Conclusions and summary -- 14 MOLECULAR INVOLVEMENT OF THE BONE MARROW MICROENVIRONMENT IN BONE METASTASIS -- 1 Introduction -- 2 Types of bone metastasis -- 3 Pathophysiology of bone metastasis -- 4 Treatment options for bone metastasis -- 5 Discussion/conclusion -- 15 AN OVERVIEW ON HEPATIC METASTASIS -- 1 Introduction -- 2 Hepatic physiology and cancer biology -- 3 Hepatic functional and surgical anatomy -- 4 Clinical presentation and diagnosis -- 5 Treatment of hepatic metastasis -- 6 Conclusions -- 16 PULMONARY METASTASIS -- 1 Development of pulmonary metastasis -- 2 Rationale for local treatment of pulmonary metastases -- 3 Diagnosis of pulmonary metastases -- 4 Preoperative exams -- 5 Surgical resection -- 6 Radiological ablation -- 7 Radiotherapy -- 8 Lymph node involvement -- 9 Resection of recurrent metastases -- 10 Lung metastasis in given tumor types -- 11 Conclusion -- 17 BRAIN METASTASIS: BASIC BIOLOGY, CLINICAL MANAGEMENT, AND INSIGHT FROM EXPERIMENTAL MODEL SYSTEMS -- 1 Introduction -- 2 Biology -- 3 Clinical management -- 4 Experimental model systems -- 5 Preclinical findings -- 6 Conclusions -- III EMERGING TARGETS FOR CANCER METASTASIS -- 18 DEVELOPMENTAL PATHWAYS: EMERGING THERAPEUTIC TARGETS FOR CANCER METASTASIS -- 1 Introduction -- 2 Prometastatic changes and developmental pathways -- 3 Notch signaling and metastasis -- 4 Antimetastatic potential of Wnt and hedgehog targeting -- 5 Concluding remarks -- 19 EMERGING THERAPEUTIC TARGETS FOR CANCER METASTASIS: FROM THE PERSPECTIVE OF EMBRYO IMPLANTATION -- 1 Introduction -- 2 The similarity between embryo implantation and tumor metastasis -- 3 Trophoblast invasion inhibitory factors derived from the maternal endometrium during embryo implantation and their implications in cancer metastasis -- 4 Conclusions and perspectives -- 20 WNT SIGNALING AS A THERAPEUTIC TARGET IN CANCER AND METASTASIS -- 1 Introduction -- 2 Wnt signaling and cancer -- 3 The role of Wnt signaling in epithelial-mesenchymal transition and cancer stem cells -- 4 Therapeutic strategies targeting Wnt signaling -- 5 Protein knockdown strategies -- 6 Viral-based therapies -- 7 Conclusion -- Index

"Introduction to Cancer Metastasis provides an overview of cancer metastais and novel therapeutic targets, all in one place. Through specific chapters on three divers topics - primary cancers and their metastasis, common metastatic sites and emerging targets for therapy - this volume comprehensively informs readers on the broader knowledge gained on cancer metastasis so far. Key features: Includes basic biology and translational approaches to organ-specific cancer sites; Provides readers with information on emerging therapeutic targets for cancer metastasis; Contains contributions from leading researchers around the globe"--P. [4] of cover.