Clinical pharmacology created by Morris J Brown; MA, MSc, FRCP, FAHA, FBPharmacolS, FMedSci; Professor of Endocrine, Hypertension - William Harvey Research Institute of Barts and the London School of Medicine and Dentistry, London, UK., Pankaj Sharma; MD, PhD, FRCP; Professor of Neurology, Director, Institute of Cardiovascular Research, Royal Holloway College, University of London; and Consultant Neurologist, Imperial College Healthcare NHS Trust, London, UK., Fraz A Mir; MA, FRCP.;Consultant Clinical Pharmacologist, Division of Experimental Medicine and Immunotherapeutics, Department of Medicine - University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. and Peter N Bennett; MD, FRCP; Formerly Reader in Clinical Pharmacology - University of Bath; Consultant Physician - Royal United Hospital, Bath, UK.

Includes an index.

1. Clinical pharmacology -- 2. Topics in drug therapy -- 3. Discovery and development of drugs -- 4. Evaluation of drugs in humans -- 5. Health technology assessment -- 6. Regulation of medicines -- 7. Classification and naming of drugs -- 8. General pharmacology -- 9. Unwanted effects and adverse drug reactions -- 10. Poisoning, overdose, antidotes -- 11. Drug dependence -- 12. Chemotherapy of infections -- 13. Antibacterial drugs -- 14. Chemotherapy of bacterial infections -- 15. Viral, fungal, protozoal and helminthic infections -- 16. Drugs for inflammation and joint disease -- 17. Drugs and the skin -- 18. Pain and analgesics -- 19. Anaesthesia and neuromuscular block -- 20. Psychotropic drugs -- 21. Neurological disorders- epilepsy, Parkinson's disease and multiple sclerosis -- 22. Cholinergic and antimuscarinic (anticholinergic) mechanisms and drugs -- 23. Adrenergic mechanisms and drugs -- 24. Arterial hypertension, angina pectoris, myocardial infarction and heart failure -- 25. Cardiac arrhythmia -- 26. Hyperlipidaemias -- 27. Kidney and genitourinary tract -- 28. Respiratory system -- 29. Drugs and haemostasis -- 30. Red blood cell disorders -- 31. Neoplastic disease and immunosuppression -- 32. Oesophagus, stomach and duodenum -- 33. Intestines -- 34. Liver and biliary tract -- 35. Adrenal corticosteroids, antagonists, corticotropin -- 36. Diabetes mellitus, insulin, oral antidiabestes agents, obesity -- 37. Thyroid hormones, antithyroid drugs -- 38. Hypothalamic, pituitary and sex hormones -- 39. Vitamins, calcium, bone.

"The twelfth edition of this long-established textbook of clinical pharmacology (first published in 1960) continues its fine tradition of balancing science and practice for improved evidence-based drug therapy and good prescribing in therapeutic settings increasingly complicated by intercurrent disease and polypharmacy"