Introduction to drug metabolism G Gordon Gibson and Paul Skett

Chapter1.- Pathaways of drug metabolism; Chapter 2 - Enzymology and molecular mechanism of drug metabolism; Chapter 3 - Induction and inhibition of drug metabolism; Chapter 4 - Factors affecting drug metabolism: internal factors; Chapter 5 - Factors affecting drug metabolism: external factors; Chapter 6 - Pharmacological and toxicological aspects of drug metabolism; Chapter 7 -The clinical relevance of drug metabolism.

widely accepted as comprehensive, well written and easy-to-read, this book provides the perfect introduction to the area of drug metabolism without peer. The basic principles of drug metabolism are covered and are still valid and appreciated by those who use this textbook. For this new edition, in order to reflect the large strides made in understanding of the subject, the content, particularly in the following areas, has been revised and updated: Human enzymes; drug- and chemical-dependent regulation of the drug-metabolizing enzymes; genetic polymorphisms and drug responses in the human population; clinical relevance of the subject; toxicological implications of drug biotransformation reactions; and enzyme nomenclature. In addition, the further reading lists have been substantially updated and the inclusion of website information is new to this edition. Each chapter contains examples that are clinically relevant , demonstrating how basic concepts underpin the uses and abuses of drugs in real life usage and each now comes with a summary of learning objectives to help the reader to get the most out of the chapter.