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SECTION 1: KIDNEY Introduction and Overview 4 Introduction to Renal Cell Tumors Satish K. Tickoo, MD and Victor E. Reuter, MD 10 Classification of Kidney Tumors and Tumor-Like Lesions Satish K. Tickoo, MD and Victor E. Reuter, MD Familial Cancer Syndromes 12 von Hippel-Lindau Syndrome Satish K. Tickoo, MD and Victor E. Reuter, MD 16 Birt-Hogg-Dubé Syndrome Satish K. Tickoo, MD and Victor E. Reuter, MD 20 Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome Satish K. Tickoo, MD, Victor E. Reuter, MD, and Mahul B. Amin, MD 24 Tuberous Sclerosis Complex Satish K. Tickoo, MD and Victor E. Reuter, MD 28 Succinate Dehydrogenase Complex Deficiency Syndrome Satish K. Tickoo, MD and Victor E. Reuter, MD 32 Hereditary Papillary Renal Cancer and Miscellaneous Other Familial Cancer Syndromes Satish K. Tickoo, MD and Victor E. Reuter, MD Nonneoplastic Lesions 38 Renal Tuberculosis, Xanthogranulomatous Pyelonephritis, Renal Malakoplakia Satish K. Tickoo, MD and Victor E. Reuter, MD Renal Cell Tumors, Benign 44 Papillary Adenoma Satish K. Tickoo, MD and Victor E. Reuter, MD 48 Renal Oncocytoma Satish K. Tickoo, MD and Victor E. Reuter, MD Renal Cell Carcinoma 54 Clear Cell Renal Cell Carcinoma Satish K. Tickoo, MD and Victor E. Reuter, MD 64 Multilocular Cystic Renal Neoplasm of Low Malignant Potential Satish K. Tickoo, MD and Victor E. Reuter, MD 68 Clear Cell Renal Cancers With Fibromyomatous Stroma, Including ELOC (Formerly TCEB1) Mutated Renal Cell Carcinoma Judy Sarungbam, MD, Satish K. Tickoo, MD, and Victor E. Reuter, MD 74 Clear Cell Papillary Renal Cell Tumor Satish K. Tickoo, MD and Victor E. Reuter, MD 82 Papillary Renal Cell Carcinoma Satish K. Tickoo, MD and Victor E. Reuter, MD 92 Chromophobe Renal Cell Carcinoma Satish K. Tickoo, MD and Victor E. Reuter, MD 100 Collecting Duct Carcinoma Satish K. Tickoo, MD and Victor E. Reuter, MD 106 SMARCB1-Deficient Renal Medullary Carcinoma and SMARCB1-Deficient Medullary-Like Renal Cell Carcinoma Satish K. Tickoo, MD and Victor E. Reuter, MD 112 TFE3- and TFEB-Rearranged Renal Cell Carcinomas Satish K. Tickoo, MD and Victor E. Reuter, MD 120 Mucinous Tubular and Spindle Cell Carcinoma Satish K. Tickoo, MD, Yingbei Chen, MD, and Victor E. Reuter, MD 126 Tubulocystic Renal Cell Carcinoma Satish K. Tickoo, MD, Judy Sarungbam, MD, and Victor E. Reuter, MD 130 Thyroid-Like Follicular Carcinoma of Kidney Satish K. Tickoo, MD and Victor E. Reuter, MD 134 Acquired Cystic Disease-Associated Renal Cell Carcinoma Satish K. Tickoo, MD and Victor E. Reuter, MD 140 Fumarate Hydratase-Deficient Renal Cell Carcinoma Jatin S. Gandhi, MD and Mahul B. Amin, MD 144 ALK Rearrangement-Associated Renal Cell Carcinoma Jatin S. Gandhi, MD and Mahul B. Amin, MD 148 Eosinophilic Solid and Cystic Renal Cell Carcinoma Jatin S. Gandhi, MD and Mahul B. Amin, MD 150 Other Eosinophilic/Oncocytic Tumors, Including ESC, EVT, and LOT Satish K. Tickoo, MD and Victor E. Reuter, MD 154 Subsequent 2nd Tumors Satish K. Tickoo, MD and Victor E. Reuter, MD 158 Renal Cell Carcinoma, Not Otherwise Specified Satish K. Tickoo, MD and Victor E. Reuter, MD Metanephric Tumors 162 Metanephric Adenoma Satish K. Tickoo, MD and Victor E. Reuter, MD 168 Metanephric Tumors Other Than Metanephric Adenoma Satish K. Tickoo, MD and Victor E. Reuter, MD Nephroblastic Tumors 172 Nephrogenic Rests Satish K. Tickoo, MD and Victor E. Reuter, MD 176 Nephroblastoma (Wilms Tumor) Satish K. Tickoo, MD and Victor E. Reuter, MD 186 Cystic Partially Differentiated Nephroblastoma Satish K. Tickoo, MD and Victor E. Reuter, MD Mesenchymal Tumors 188 Angiomyolipoma Satish K. Tickoo, MD and Victor E. Reuter, MD 194 Epithelioid Angiomyolipoma/Epithelioid PEComa Satish K. Tickoo, MD and Victor E. Reuter, MD 200 Congenital Mesoblastic Nephroma Satish K. Tickoo, MD and Victor E. Reuter, MD 204 Clear Cell Sarcoma of Kidney Satish K. Tickoo, MD and Victor E. Reuter, MD 208 Rhabdoid Tumor of Kidney Satish K. Tickoo, MD and Victor E. Reuter, MD Mixed Mesenchymal and Epithelial Tumors 212 Mixed Epithelial and Stromal Tumor (MEST) Family Tumors Satish K. Tickoo, MD and Victor E. Reuter, MD 220 Pediatric Cystic Nephroma Satish K. Tickoo, MD and Victor E. Reuter, MD 224 Synovial Sarcoma Satish K. Tickoo, MD and Victor E. Reuter, MD Neuroendocrine Tumors 228 Renal Neuroendocrine Tumor/Carcinoid Tumor and Neuroendocrine Carcinoma Satish K. Tickoo, MD and Victor E. Reuter, MD 232 Renal Ewing Sarcoma Satish K. Tickoo, MD and Victor E. Reuter, MD Hematopoietic Tumors 236 Hematopoietic Tumors Satish K. Tickoo, MD, Judy Sarungbam, MD, and Victor E. Reuter, MD Metastatic and Other Tumors 242 Juxtaglomerular Cell Tumor (Reninoma) Satish K. Tickoo, MD and Victor E. Reuter, MD 246 Renomedullary Interstitial Cell Tumor Satish K. Tickoo, MD and Victor E. Reuter, MD 250 Other Rare Tumors Satish K. Tickoo, MD and Victor E. Reuter, MD 258 Metastatic Tumors Satish K. Tickoo, MD and Victor E. Reuter, MD Immunohistochemical Profiles for Tumors Involving Kidney 262 Immunohistochemistry, Kidney Satish K. Tickoo, MD and Victor E. Reuter, MD SECTION 2 Introduction and Overview 270 Classification of Bladder Tumors and Tumor-Like Lesions Steven Christopher Smith, MD, PhD Microscopic Anatomy 272 Microscopic Anatomy of Urinary Bladder Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD 276 Microscopic Anatomy of Urethra Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD 280 Microscopic Anatomy of Ureter Steven Christopher Smith, MD, PhD 282 Microscopic Anatomy of Renal Pelvis Steven Christopher Smith, MD, PhD Nonneoplastic Lesions of Urinary Tract 286 Overview of Cystitis Steven Christopher Smith, MD, PhD 292 Polypoid Cystitis Steven Christopher Smith, MD, PhD 300 Malakoplakia Steven Christopher Smith, MD, PhD 306 Schistosomiasis Steven Christopher Smith, MD, PhD 308 von Brunn Nests Steven Christopher Smith, MD, PhD 314 Nephrogenic Adenoma (Metaplasia) Steven Christopher Smith, MD, PhD 322 Fibroepithelial Polyp Steven Christopher Smith, MD, PhD 326 Prostatic-Type Polyp (Ectopic Prostate) Steven Christopher Smith, MD, PhD 330 Amyloidosis Steven Christopher Smith, MD, PhD 332 Müllerian Lesions Steven Christopher Smith, MD, PhD 336 Pseudocarcinomatous Hyperplasia Steven Christopher Smith, MD, PhD 344 Hamartoma Steven Christopher Smith, MD, PhD Urothelial Neoplasms, General 346 Overview of Urinary Bladder Neoplasms Hikmat Al-Ahmadie, MD Flat Urothelial Lesions 350 Urothelial Carcinoma In Situ Steven Christopher Smith, MD, PhD 358 Flat Urothelial Lesions Other Than Carcinoma In Situ Steven Christopher Smith, MD, PhD UROTHELIAL NEOPLASMS, NONINVASIVE 362 Atypical Urothelial Proliferations, Flat and Tented Type (Formerly Flat and Papillary Hyperplasia) Jatin S. Gandhi, MD and Mahul B. Amin, MD 364 Urothelial Papilloma Steven Christopher Smith, MD, PhD 370 Papillary Urothelial Neoplasm of Low Malignant Potential Steven Christopher Smith, MD, PhD 374 Low-Grade Papillary Urothelial Carcinoma Hikmat Al-Ahmadie, MD 378 High-Grade Papillary Urothelial Carcinoma Hikmat Al-Ahmadie, MD 384 Inverted Urothelial Neoplasia Steven Christopher Smith, MD, PhD Urothelial Neoplasms, Invasive 394 Invasive Urothelial Carcinoma Hikmat Al-Ahmadie, MD 404 Urothelial Carcinoma, Subtypes and Divergent Differentiation Steven Christopher Smith, MD, PhD Glandular Lesions 426 Cystitis Cystica et Glandularis Hikmat Al-Ahmadie, MD 430 Villous Adenoma Hikmat Al-Ahmadie, MD 432 Invasive Adenocarcinoma Hikmat Al-Ahmadie, MD 438 Clear Cell Adenocarcinoma Hikmat Al-Ahmadie, MD Squamous Lesions 444 Squamous Proliferations Other Than Carcinoma Hikmat Al-Ahmadie, MD 448 Invasive Squamous Cell Carcinoma Hikmat Al-Ahmadie, MD Mesenchymal Lesions 454 Myofibroblastic Proliferations Steven Christopher Smith, MD, PhD 462 Smooth Muscle Tumors Steven Christopher Smith, MD, PhD 470 Rhabdomyosarcoma Steven Christopher Smith, MD, PhD 476 Other Mesenchymal Tumors Steven Christopher Smith, MD, PhD Other Tumors of Urinary Bladder 484 Paraganglioma Steven Christopher Smith, MD, PhD 492 Metastatic/Secondary Involvement of Bladder Steven Christopher Smith, MD, PhD Diverticula of Urinary Tract 500 Diverticula Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD 504 Diverticular-Associated Neoplasia Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD URETHRA 508 Inflammatory Lesions of Urethra Steven Christopher Smith, MD, PhD 512 Carcinoma of Urethra Steven Christopher Smith, MD, PhD 516 Other Tumors and Tumor-Like Lesions of Urethra Steven Christopher Smith, MD, PhD URETER 520 Urothelial Carcinoma of Ureter Hikmat Al-Ahmadie, MD 524 Other Tumors and Tumor-Like Lesions of Ureter Hikmat Al-Ahmadie, MD RENAL PELVIS 530 Urothelial Carcinoma of Renal Pelvis Hikmat Al-Ahmadie, MD 540 Other Tumors and Tumor-Like Lesions of Renal elvis Hikmat Al-Ahmadie, MD Urachs 546 Urachal Remnants Steven Christopher Smith, MD, PhD 548 Tumors of Urachus Steven Christopher Smith, MD, PhD Immunohistochemical Profiles for Tumors Involving Urinary Bladder 554 Immunohistochemistry, Urinary Tract Steven Christopher Smith, MD, PhD SECTION 3: PROSTATE GLAND AND SEMINAL VESICLE Introduction and Overview 562 Classification of Prostate Tumors and Tumor-Like Lesions Gladell P. Paner, MD, (BS) MT 564 General Concepts, Prostate Gladell P. Paner, MD, (BS) MT 570 Microanatomy and Zonal Variations Gladell P. Paner, MD, (BS) MT 580 Imaging Considerations for Pathologists Steven Christopher Smith, MD, PhD NONNEOPLASTIC LESIONS 584 Prostatitis Steven Christopher Smith, MD, PhD 588 Prostate Hyperplasia Gladell P. Paner, MD, (BS) MT 596 Adenosis Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD 600 Atrophy and Its Patterns Gladell P. Paner, MD, (BS) MT 606 Hyperplasia of Mesonephric Remnants Steven Christopher Smith, MD, PhD 610 Verumontanum Mucosal Gland Hyperplasia Gladell P. Paner, MD, (BS) MT and Deepika Sirohi, MD 612 Nephrogenic Adenoma (Metaplasia) of Prostatic Urethra Gladell P. Paner, MD, (BS) MT PUTATIVE PREMALIGNANT LESIONS AND LESIONS FALLING SHORT OF MALIGNANT DIAGNOSIS 620 Prostatic Intraepithelial Neoplasia Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD Prostate Neoplasms 630 General Concepts, Prostate Carcinoma Steven Christopher Smith, MD, PhD 638 Acinar Adenocarcinoma Gladell P. Paner, MD, (BS) MT 656 Acinar Adenocarcinoma Subtypes and Patterns Gladell P. Paner, MD, (BS) MT 668 Atypical Small Acinar Proliferations Steven Christopher Smith, MD, PhD 674 Intraductal Proliferations and Ductal Carcinoma Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD 682 Ductal Adenocarcinoma Gladell P. Paner, MD, (BS) MT 690 Urothelial Carcinoma Involving Prostate Gland Steven Christopher Smith, MD, PhD 696 Prostate Carcinoma With Neuroendocrine Differentiation Steven Christopher Smith, MD, PhD 704 Adenoid Cystic (Basal Cell) Carcinoma of Prostate Steven Christopher Smith, MD, PhD 710 Sarcomatoid Carcinoma of Prostate Steven Christopher Smith, MD, PhD 716 Carcinomas With Squamous Differentiation Gladell P. Paner, MD, (BS) MT 722 Cystic Epithelial Tumors of Prostate Gladell P. Paner, MD, (BS) MT |